GABAergic effects of some foods extracts via inhibition of GABA transaminase (GABA-T)

Objective: GABAergic system is a target for various groups of medications including sedatives, anxiolytics, muscle relaxants, antidepressants and antiepileptics. Several foods or food ingredients are able to affect the by inhibition γ-aminobutyric acid (GABA) degrading enzymes GABA-transaminase succinate semialdehyde dehydrogenase. The purpose this study investigate inhibitory effects tea (Camellia sinensis), coffee (Coffea arabica L.), peppermint (Mentha piperita thyme (Thymus vulgaris cinnamon (Cinnamomum zeylanicum) on GABA enzymes.Methods: GABA-T aqueous extracts zeylanicum), L.) was investigated using fluorometric microplate enzyme assay. Dose-dependent GABA-degrading attained all tested. For determination IC50 values (± 95 % CI), linear regression performed Origin® (Origin® 2015G von Origin Lab Corporation, Northampton, MA 01060 USA).Results: extract black presented strongest activity with an IC50-value (half maximal concentration) 13.0 (11.0-15.3) µg/mL. tested were successful in inhibiting even at low concentrations. Conclusion: In conclusion, selected could serve as natural inhibitors thus, they increase concentration brain.